Friday, April 26, 2013

Amazon reports lower 1Q earnings, higher revenue

SEATTLE (AP) ? Amazon.com says its net income declined in the first three months of the year even though revenue increased 22 percent, as its expenses continued to grow.

Amazon.com Inc. said Thursday that it earned $82 million, or 18 cents per share, in the first quarter. That's down 37 percent from $130 million, or 28 cents per share, in the same period a year earlier. But it's higher than the 7 cents expected by analysts polled by FactSet.

Revenue rose 22 percent to $16.07 billion, from $13.19 billion. Analysts expected $16.14 billion.

Amazon's operating expenses rose 22 percent to $15.9 billion, from $13 billion.

Amazon says it expects revenue of $14.5 billion to $16.2 billion for the current quarter. Analysts had expected $15.92 billion.

Source: http://news.yahoo.com/amazon-reports-lower-1q-earnings-higher-revenue-202944865--finance.html

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The perfect picnic | Life and style | The Guardian

Spicy chickpea egg

Spicy chickpea eggs will liven up any picnic

A couple of weeks ago, as weak sunshine dribbled through gusty clouds, I?walked through a park at lunchtime. The grass, straggly and still damp after the long winter, was none the less playing host to numerous office workers, perched awkwardly on their coats, grimly enjoying an al fresco lunch. The British don't let a little thing like weather spoil a picnic. indeed, in hot Mediterranean climates, when everyone with any sense retreats indoors for lunch, you'll often find familiar-looking families happily taking their ease in the midday sun. nothing gets between us and the tupperware, not even sunstroke ? our commitment to the rug in defiance of all good sense is one of our most endearing national characteristics.

Happily, it looks like it's brightening up at last, but, although the sunshine does make everything taste nicer, there's no harm in seasoning proceedings with a pinch of expertise.

Pick your spot carefully

Delia Smith manages to make picnicking sound utterly joyless: "In French films," she writes in her Complete Cookery Course, "picnics are all about rivers and willow and punts. In Britain, the hot tarmac of the zoo car-park will do, or a patch of grass with four lanes of traffic on either side." Ah, the romance. If you can't find any hot tarmac, a beauty spot will work better. An American household manual from 1900 suggests ensuring a "reasonable freedom from tormenting insect life", but advises against settling in the shadow of some lofty peak, or famous cave, on the grounds that: "One does not feel too comfortable when banqueting in localities where Dame Nature has had her queer moods, and has left imprinted certain too observable evidences of her freakiness." That's my local park out then.

If you're just shouldering a few sandwiches and an Enid Blyton-esque rosy apple, then make straight for the hills, but those going all-out on catering should stick close to a friendly car park or railway station. In the event of uncertain skies, a canny picnicker will select a spot near a hospitable pub.

Travel light(ish)

Ideally, all picnics would be conducted around the capacious wicker baskets that Elizabeth David describes as having "an aura of lavish gallivantings and ancient Rolls-Royces". However,, unless you've got a vintage sports car to cart them about in, they are hopelessly impractical; better to go in what the 1908 New York Times Cookbook calls "light marching order".

Even if carrying it all in an old knapsack, real cutlery, plates and a jaunty woollen rug preferably with a waterproof back,are still a must for atmosphere. Corkscrews, bottle openers, wet wipes and a sharp knife are also useful. And mustard. You can't have a picnic without mustard.

Food and drink

Mrs Beeton suggests: "A joint of cold roast beef, a joint of cold boiled beef, 2 ribs of lamb, 2 shoulders of lamb, 4 roast fowls, 2 roast ducks, 1 ham, 1 tongue, 2 veal-and-ham pies, 2 pigeon pies, 6 medium-sized lobsters, 1 piece of collared calf's head ?" just for the meat course.

Thankfully, times have changed. Hilda Leyel, author of the magnificent 1936 work The Perfect Picnic, wisely observes that "the art of arranging meals is to choose dishes that are better cold than they would be hot". For her, this means cream of rabbit, spaghetti and truffle salad and devilled lamb with a nasturtium sauce. The modern reader should infer salads (indeed the Girls Own Paper of 1880 advises that 'a cucumber is indispensable! The picnic would not be a picnic if it were absent'), pies, cheeses and the like, but, as David says, keep things simple. "Foie gras and lobster patties ? seem to lose their fine lustre out of doors," she writes (and I sense you all nodding in agreement), before grandly conceding that "sandwiches, I rather like". Bear in mind probable temperatures: it's all very well serving pink champagne, lobster and caviar if you're Keith Floyd on a boat at the bottom of your garden, but if the food and drink is going to be sitting around, cider and a nice ripe brie will go down better.

David suggests "visiting the site of the intended picnic some days beforehand" to bury the champagne. I'm not sure I'd give White Lightning 10 minutes unattended round my way ? so if you can't keep white wine cool en route, choose something else. She suggests m?con or chianti, but I fear the art of drinking strong reds in the sun is a dying one. Frankly ale, cider ("many women like cider," Leyel helpfully observes) or good lemonade are better bets on a picnic, and, "if a liqueur is wanted, cherry brandy is a very appropriate one". Hear hear.

Perfect picnic recipes

Chicken, chorizo and pepper pies These chicken pies are bursting with flavour

Chicken, chorizo and pepper pies

Veggie scotch eggs

Coconut and cardamom ice

Alcoholic lemonade

Source: http://www.guardian.co.uk/lifeandstyle/wordofmouth/2013/apr/24/the-perfect-picnic-felicity-cloake

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Functional potential of genes: Pushing the boundaries of transcription

Apr. 24, 2013 ? Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of messenger RNAs (mRNAs) that such start and end variation produces, even from the simple genome of yeast cells. Their findings, published today in Nature, shed new light on the importance of mRNA boundaries in determining the functional potential of genes.

Hundreds of thousands of unique mRNA transcripts are generated from a genome of only about 8000 genes, even with the same genome sequence and environmental condition. "We knew that transcription could lead to a certain amount of diversity, but we were not expecting it to be so vast," explains Lars Steinmetz, who led the project. "Based on this diversity, we would expect that no yeast cell has the same set of messenger RNA molecules as its neighbour."

The traditional understanding of transcription was that mRNA boundaries were relatively fixed. While it has long been known that certain parts of mRNAs can be selectively 'spliced' out, this phenomenon is very rare in baker's yeast, meaning that the textbook one gene -- one mRNA transcript relationship should hold. Recent studies have suggested that things aren't quite that simple, inspiring the EMBL scientists to create a new technique to capture both the start and end points of single mRNA molecules. They now discovered that each gene could be transcribed into dozens or even hundreds of unique mRNA molecules, each with different boundaries.

This suggests that not only transcript abundance, but also transcript boundaries should be considered when assessing gene function. Altering the boundaries of mRNA molecules can affect how long they stay intact, cause them to produce different proteins, or direct them or their protein products to different locations, which can have a profound biological impact. Diversifying mRNA transcript boundaries within a group of cells, therefore, could equip them to adapt to different external challenges.

The researchers expect that such an extent of boundary variation will also be found in more complex organisms, including humans, where some examples are already known to affect key biological functions. The technology to measure these variations across the entire genome as well as a catalogue of boundaries in a well-studied organism are a good starting point for further research. "Now that we are aware of how much diversity there is, we can start to figure out what factors control it," points out Vicent Pelechano, who performed the study with Wu Wei. Wei adds: "Our technique also exposed new mRNAs that other techniques could not distinguish. It will be exciting to investigate how these and general variation in transcript boundaries actually extend the functional capacity of a genome."

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Story Source:

The above story is reprinted from materials provided by European Molecular Biology Laboratory (EMBL).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Vicent Pelechano, Wu Wei, Lars M. Steinmetz. Extensive transcriptional heterogeneity revealed by isoform profiling. Nature, 2013; DOI: 10.1038/nature12121

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/3bZaIH7i0xo/130424132645.htm

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Thursday, April 25, 2013

Why These 2016 Democratic Hopefuls Aren't Shying Away From Gun Control (Atlantic Politics Channel)

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Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/301313320?client_source=feed&format=rss

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Missouri House backs income tax cut, sales tax hike - KansasCity.com

? Legislation aimed at countering massive tax cuts passed last year in Kansas cleared the Missouri House on Wednesday, putting it one vote away from the governor?s desk.

The legislation was approved by the House on a 90-68 vote, with 18 Republicans joining Democrats in opposition. That puts the bill far short of the 109 votes needed to override a veto by Gov. Jay Nixon, who earlier this year criticized the measure as a tax increase on working families and senior citizens.

The bill would gradually reduce the top individual income tax rate by two-thirds of a percent and the corporate tax rate by three-quarters of a percent. The reductions would happen over five years as long as revenue grows at least $100 million in a given year.

It also would create a 50 percent tax deduction for all businesses.

To offset some of the cost of the tax cuts, the bill gradually increases the sales tax by three-fifths of a cent, with the additional money going to schools, a new mental hospital and roads.

?I wish this tax cut would be more, but I have to pause and realize the historic nature of what we?re doing today,? said Rep. Eric Burlison, a Springfield Republican.

The bill also includes a provision making it easier to collect sales taxes on Internet purchases and creates an amnesty period in which delinquent taxpayers could pay without penalty.

Proponents of the plan say it will make Missouri more competitive with Kansas, which last year slashed state income taxes and eliminated them entirely for nearly 200,000 businesses.

Critics, however, say the result of the legislation will be budget shortfalls that will force cuts to programs like K-12 education, which is already underfunded by $600 million. When fully phased in, the tax changes in the bill are estimated to reduce state revenue by $300 million to $500 million.

?Someone, whether it?s our public education system or our senior citizens, is going to have to bear the brunt of this in the future,? said Rep. Jon Carpenter, a Kansas City Democrat.

The Senate, which passed a different version earlier this year, is expected to debate the measure Thursday morning. Republicans can agree to the changes made in the House and send the bill to the governor or ask for a conference committee to work out differences.

Source: http://www.kansascity.com/2013/04/24/4200709/missouri-house-backs-income-tax.html

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BBC plans 'Tweet of the Day,' radio for birds

LONDON (AP) ? Remember when tweeting was for the birds?

The BBC is hoping to revive that simpler time with "Tweet of the Day" ? an early-morning radio program dedicated to British birdsong.

Veteran naturalist David Attenborough will host the 90-second show, which will feature the song of a different bird each weekday, along with background on the species' behavior and habits.

The show on the BBC's main speech station, Radio 4, may be best appreciated by those who rise with the birds. "Tweet of the Day" will be broadcast at 5:58 a.m.

The BBC said Wednesday that 265 different birds will be featured during the year-long series, which begins next month with a recording of the cuckoo. Attenborough will host for the first month, and be followed by other BBC presenters.

Source: http://news.yahoo.com/bbc-plans-tweet-day-radio-birds-112446764.html

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China sends largest fleet yet to disputed islands

China sent a fleet of patrol ships today to the sea area it disputes with Japan, following a controversial visit by Japanese officials to a war shrine. The latest moves are seen as a setback for a diplomatic resolution.

By Ralph Jennings,?Correspondent / April 23, 2013

Chinese surveillance ships sail in formation in waters claimed by Japan near disputed islands called Senkaku in Japan and Diaoyu in China in the East China Sea Tuesday.

Kyodo News/AP

Enlarge

Spats between Asia?s two most powerful nations, China and Japan, have grown uncomfortably routine since Tokyo nationalized a group of disputed islands in September. On Tuesday tensions reached a new and potentially worrisome high.

Skip to next paragraph Ralph Jennings

Taiwan Correspondent

Ralph Jennings has covered news in China, Taiwan and Southeast Asia for the past 14 years. He lives in Taipei and holds a degree in mass communication from the University of California in Berkeley.?

Recent posts

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China sent eight surveillance vessels into Japanese territorial waters, apparently to track a flotilla of Japanese activists who had gone to look at the contested area. China?s presence ? an effort to exercise authority in the region ? is its largest since Japan nationalized the uninhabited islets, Kyodo News reported.

China?s use of ships in disputed waters isn?t expected to cause a war, but it raises the specter of a miscalculation at sea that could in turn create a new diplomatic row, set off more protests in Chinese cities, and strike another blow at Japanese business caught in the crossfire. Hopes of polite negotiations are also off the map for now.

"Only when Japan faces up to its aggressive past can it embrace the future and develop friendly relations with its Asian neighbors," Chinese foreign ministry spokeswoman Hua Chunying told a news conference on Monday.

As if the 80 pro-Tokyo activists weren?t enough to upset Beijing, that same day 168 Japanese lawmakers visited a Shinto shrine that?s reviled elsewhere in Asia for memorializing World War II heroes. Japan occupied parts of China from 1931 to 1945. Three cabinet ministers had already visited Yasukuni Shrine over the weekend, causing calculated reaction.

In protest, a high-level Chinese military official bailed on a trip this week to Japan as the foreign ministry lashed out.?

And China?s surveillance vessels probably weren?t loaded with olive branches. The Communist country has increasingly jousted?with Japan since around 2005 as it rose to become the world?s second largest economy.

?Such an intrusion [in the East China Sea] was certainly not undertaken spontaneously, but would have been planned and coordinated some time in advance for execution as soon as an opportunity presented itself,? says Scott Harold, associate political scientist with US-based think tank the RAND Corporation.

Japan controls the disputed islets, which it calls the Senkakus, despite 40 years of competing claims from China and a wave of destructive anti-Japanese street protests in Chinese cities last year. China criticizes the Shinto shrine visits because a memorial at the venue also honors 14 major war criminals.

The two sides are also disputing rights to an undersea natural gas field, while China periodically accuses Japan of not apologizing for the war of the 1940s. Japan says it has apologized.?

China and Japan, as the world?s No. 2 and No. 3 economies, also mean a lot to each other trade wise. The number of Japanese subsidiaries in China has grown eight times since the 1990s, and they sold $147 billion worth of goods to the country in the 2011 fiscal year.

Will the two keep meeting, along with South Korea, to discuss a three-way trade agreement? After momentum last month, the latest raises concern that this puts progress on ice.

?Both sides need to be more flexible,? suggests Ralph Cossa, president with US think tank Pacific Forum Center for Strategic and International Studies. ?Japan needs to acknowledge that the territory is in dispute, at least from a Chinese perspective, and the Chinese need to acknowledge that they are under Japan?s administrative control and that a military solution is unacceptable.?

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/JNlHK-p_sik/China-sends-largest-fleet-yet-to-disputed-islands

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