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Tuesday, May 22, 2012
Why Airplanes Still Have Ashtrays in the Bathrooms [Airplanes]
Ann Arbor Firm Helps Analyze Lethal, Castration-Resistant Prostate ...
ANN ARBOR ? A new study by researchers from the University of Michigan, Yale School of Public Health, Brown University and Ann Arbor-based Compendia Bioscience provided a comprehensive genomic profiling of patients with pre-treated lethal metastatic prostate cancer, providing insights into mechanisms of resistance.
The study, published in the scientific journal Nature, identified a diverse series of likely driving mutations and copy number alterations in both known and novel genes. Oncomine streamlined analysis of genome alterations and provided a platform for rapid validation across previously published studies.
?The Oncomine?tool set was developed to mine the global collection of cancer genomic data ? our most recent advances focusing on mutation and copy number analysis. It is always rewarding to see our platform contributing to scientific discovery,? said Dr. Daniel Rhodes, CEO of Compendia Bioscience.
Integrated analysis of copy number and mutation data identified loss of CHD1, a chromatin-modifying enzyme, as a key genetic event in ETS-negative prostate cancer. With Oncomine, the team was able to rapidly validate this observation across 13 independent, previously published patient cohorts.
?Oncomine?continues to be my go-to reference database to analyze and validate cancer genomic findings,? said Dr. Scott Tomlins, senior author of the study. ?The latest advances in mutation and copy number analysis are quite powerful and the ability to quickly and easily compare multiple data sets is unmatched.?
Compendia Bioscience is dedicated to curing cancers through the application of genomic data by providing researchers with the data and analysis tools necessary to validate biomarker and gene target discoveries, better understand mechanisms of disease, and optimize clinical outcomes. Visit www.compendiabio.com for more information.
Oncomine?combines a rapidly growing compendium of more than 62,000 expertly curated cancer genomic profiles with a sophisticated analysis engine and a powerful web application for data mining and visualization. Oncomine facilitates target discovery and validation and supports the prioritization of tumor populations for drug development. Visit www.oncomine.com for more information.
More at www.compendiabio.com.
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Minecraft mod adds programmable 8-bit computer, lacks cassette deck (video)
Never one to focus exclusively on the very latest hardware, a new mod has brought an 6502 microprocessor to a Minecraft world near you. The system is made from three separate cubes, representing the CPU, monitor and disk drive, respectively, all connected by ribbon cables. Part of pre-release 5 of the RedPower 2 mod, programmer Eloraam has also thrown in pumps and solar panels to keep crafters busy -- you're no longer limited to light switches. The emulated 8-bit processor can interact with other Minecraft blocks and while the computer can be programmed alone, its creator has been kind enough to include a Forth interpreter alongside the hardware, for those looking to get a little more involved. Such types can also skip over the break for an intense 23-minute tutorial on the mod.
Continue reading Minecraft mod adds programmable 8-bit computer, lacks cassette deck (video)
Minecraft mod adds programmable 8-bit computer, lacks cassette deck (video) originally appeared on Engadget on Mon, 21 May 2012 17:16:00 EDT. Please see our terms for use of feeds.
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Sunday, May 20, 2012
news: Conservative politics in the current united states of america ...
The basic tenets of conservative politics were first writ by the philosopher John Locke, an english philosopher and physician who's considered by many to be one of the founding fathers of modern thought. Locke was an atheist who believed in the supremacy of secular humanism - in other words, he believed that if humans were allowed to proceed unencumbered through life by either theocratic superstition or governmental interference, that we could achieve our greatest potential as citizens of the world. His theories were influential from Russia to the Americas, and had a profound impact upon the founding fathers of the united states, with special notation for his contributions to liberal theory.
And that's the funny part: Conservative politics have their roots in liberal theory. Conservatism as it is now, of course, is not Locke's conservatism at all, but that kind of irony tends to be lost on people who consider themselves conservatives.
Conservative politics these days are vastly different from Locke's liberal theory, though of course most conservatives still pay lip service to the notion of non-interference from government interest. Of course, they do so for a different reason. Locke's motivation was to produce a free and unencumbered people able to proceed through life on and by their own means, repressed by none and free to communicate with all.
Conservative politics today, on the other hand, focus on a lack of governmental interference in order to maintain the stratification of the classes. Government policies as a whole tend to be aimed toward things that will help the working and middle classes - stuff like jobs programs, health care, welfare, unemployment benefits and the like. These programs are pricy, but on balance they more than pay for themselves by providing jobs and training and helping the underclass gain some sort of enfranchisement.
Conservative politics tend to say they oppose that - and all government spending - in principle. However, you'll find very few conservatives who oppose military spending, the bank bailout, or other governmental programs that favor big business. So they're clearly not in tune with the principles that Locke put forth. They merely pick and choose the talking points that most favor themselves for their upcoming campaigns.
And that's without even touching Locke's other premise - that religion is superstition and god is a crutch used to oppress the working class. If you can find a single conservative in modern America who held those views, you'd have found literally one-in-a-million.
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Serena Williams withdraws with back injury
Serena Williams, of the United States, returns the ball to Italy's Flavia Pennetta during their quarter of final match at the Italian Open tennis tournament, in Rome, Friday, May 18, 2012. (AP Photo/Alessandra Tarantino)
Serena Williams, of the United States, returns the ball to Italy's Flavia Pennetta during their quarter of final match at the Italian Open tennis tournament, in Rome, Friday, May 18, 2012. (AP Photo/Alessandra Tarantino)
ROME (AP) ? Serena Williams withdrew from the Italian Open with a lower back injury shortly before she was scheduled to meet French Open champion Li Na in the semifinals on Saturday.
Williams said the problem also affected her earlier this week.
"It was feeling a little stiff and I don't think this is the right moment to force (it)," she said. "I just want to relax and get ready for the next few months."
The withdrawal comes eight days before the French Open, but Williams said the move was mainly precautionary and that she'll be ready for the clay-court major.
"This is a good week to get better and I'm confident that I'll be 100 percent," she said.
The decision ended Williams' winning streak at 17 matches. She had won consecutive titles in Charleston, South Carolina, and Madrid, plus two matches in Fed Cup.
In the Rome final, Li will face either defending champion Maria Sharapova or 11th-seeded Angelique Kerber of Germany, who were playing later.
The men's semifinals feature five-time Rome champion Rafael Nadal against fellow Spaniard David Ferrer and top-ranked Novak Djokovic vs. Roger Federer.
Several other players are also nursing injuries.
Fourth-ranked Andy Murray skipped last week's Madrid Open with a back problem and said it was still affecting him after a three-set loss to Richard Gasquet in the third round this week.
Wimbledon champion Petra Kvitova was bothered by an abdominal injury in a three-set loss to Kerber in the quarterfinals. And Italy's Flavia Pennetta retired with a right wrist injury while trailing Williams 4-0 in the first set Friday.
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Former Israeli PM: Jerusalem must be partitioned
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Locating Quick Products For Outsourcing Results | Honest Reviews ...
A vital element that has become a part of operating a successful Internet business these days is outsourcing. Being triumphant in the growth of business is something that many of the most well known Internet marketers and wepreneurs are experiencing. Outsourcing is not the most recent thing being put to use by multi-national corporations, in face it has been around for quite awhile. But due to the advent of the Internet, anyone with a formidable budget can begin to outsource his business tasks. So the question that comes about in this situation is what do you need to do in order to be certain of success with outsourcing? Within this article, we will be talking about some hints for understanding outsourcing.
One thing you should keep in mind is that outsourcing is money that you?re investing for future returns, not money you?re spending on something frivolous. You may be wary of outsourcing because you see it as an expense that you can?t afford.
Yet, it can actually be a way to save money if you do it right. Outsourcing frees up your time which helps you expand your business. When you handle everything yourself, there?s little time left over to think creatively or productively. When you outsource intelligently, then, it?s money well spent that will enable you to focus on your long term goals. One blunder that a lot of online marketers happen to make is that they pick out a vendor, based entirely on their price. While it is not a bad thing to pay attention to your investments and saving money, you should not close your eyes to the other stuff also. If you find a vendor with a good track record, then go for him even if the price is a bit more. If you are going to invest in an asset, then make it in the proper location. It does not take much to be stuck on a vendor who costs less. Although you should be focused on every single factor, including the how much it costs.
Don?t panic or get discouraged if you find that you made a mistake or overlooked something. Even experienced marketers make the occasional mistake, so don?t be too hard on yourself. This isn?t a sign that you should quit, only that you should minimize your losses and move on. Anytime you make a mistake, see what can be learned from it and you?ll emerge wiser than you were before. This is the only way you?ll be able to keep up your outsourcing adventures and ensure that you get the best return on investment. There?s really no such thing as failure unless you decide to quit.
There are all kinds of benefits to outsourcing. Outsourcing if often preferable than hiring employees for your business. It?s often surprisingly reasonable to outsource some of your most tedious daily tasks. At the same time, a larger budget will enable you to afford the services of more professional and experienced freelancers. If you?re looking for the best possible vendors, then, you have to be ready to pay their rates. Outsourcing can become a real boon to any business, so it?s something you should take advantage of.
Take a look at my website for in-depth specifics here: at home std test and scottdsmith ? what?s required.
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