Source: http://feeds.gawker.com/~r/gizmodo/full/~3/jUdK0uo6Am8/the-red-solo-cup-gets-classy
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Friday, March 8, 2013
The Red Solo Cup Gets Classy
Celldex 4Q loss widens on higher R&D costs
NEEDHAM, Mass. (AP) -- Cancer drug developer Celldex Therapeutics Inc. said Thursday its fourth-quarter loss widened as higher clinical trial expenses boosted its research and development costs.
For the quarter ended Dec. 31, the Needham, Mass.-based company posted a loss of $16.8 million, or 27 cents per share, compared with a loss of $12.7 million, or 29 cents per share, in the same quarter a year earlier.
The recent quarter's results are based on 62.5 million outstanding shares, up 42 percent from the year-ago quarter.
Revenue jumped 50 percent to $3.6 million from $2.4 million.
The loss was larger than Wall Street expected, but the company's revenue beat predictions. Analysts, on average, expected a loss of 25 cents per share on $2.5 million in revenue, according to FactSet.
Research and development expenses jumped 40 percent to $13.7 million on higher costs related to a potential brain cancer treatment that the company is developing.
For the full year 2012, Celldex posted a loss of $59.1 million, or $1.02 per share, compared with a loss of $44.8 million, or $1.13 per share, in 2011. Revenue increased to $11.2 million from $9.3 million.
Celldex shares fell 33 cents, or 3 percent, to $10.67 in afternoon trading after dropping as low as $9.13 earlier in the day. Over the past 52 weeks, the stock has traded between $3.52 and $11.24.
Source: http://news.yahoo.com/celldex-4q-loss-widens-higher-183725088.html
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Thursday, March 7, 2013
Do more women need diabetes care when pregnant?
WASHINGTON (AP) ? A change in testing could nearly triple the number of women diagnosed with diabetes during pregnancy, but would catching milder cases help mother or baby? A government panel is urging more research to find that out before doctors make the switch.
Gestational diabetes ? the kind that strikes during pregnancy ? is a growing problem. More women are getting it as they wait until their 30s or later to have a baby, and as they increasingly begin their pregnancies already overweight.
This is one of the most common complications of pregnancy, and just about every woman gets checked for it. That's because if mom's high blood sugar isn't controlled, the fetus can grow too large, leading to C-sections and early deliveries.
There are other problems, too: Mom can get dangerous high blood pressure; the baby can be born with low blood sugar; the baby's risk of obesity in childhood is increased. And while this kind of diabetes usually disappears when the baby's born, the mother is left with another risk. Months or years later, half of women who had it wind up developing full-fledged Type 2 diabetes.
Doctors today diagnose gestational diabetes in about 5 percent to 6 percent of U.S. pregnancies, or about 240,000 a year, according to experts convened this week by the National Institutes of Health.
Most U.S. doctors use a two-step testing method. But now there's a push for doctors to switch to a simpler one-step test that's used in other parts of the world.
The one-step approach, backed by the American Diabetes Association and World Health Organization, isn't just about the convenience of getting diagnosed in one doctor visit or two. It also would lower the blood sugar threshold for diagnosing the condition.
"The implications of this are very, very large, and there are so many unanswered questions," said Dr. Catherine Spong of the National Institute of Child Health and Human Development.
On Wednesday, the NIH-appointed panel agreed, and said many more pregnant women would be classified with gestational diabetes ? 15 to 20 percent ? if doctors widely adopted the one-step approach.
The more aggressive approach treats milder cases with diet and exercise, not medication. But that's still a lot of women who would get extra medical care, such as nutritionist visits and doctor checks of their blood sugar and their baby's growth, not to mention uncertainty about whether C-sections would increase. That could add up to hundreds of millions of dollars in health costs annually.
But there's been no study of whether treating cases milder than are diagnosed today makes any difference to the health of mother and baby, the experts concluded.
"If we can extend benefits to mothers, their unborn children ... and impact their future health care, everybody would want to get on board even if it were more expensive," said Dr. Peter VanDorsten of the Medical University of South Carolina. He chaired the NIH panel. Doctors aren't required to follow its advice.
He called for quick research to settle the debate, saying, "We absolutely left the door ajar for reconsideration."
What's the test? Under the two-step method, nearly every woman drinks a super-sweet liquid, and has a blood test an hour later to see how the body processes the sugar. Those who fail repeat the test with a larger drink and three hours of blood tests. With the one-step method, everyone would get a single two-hour test.
The push to switch came after a study of 25,000 pregnant women in nine countries. It found that various health risks for mother and child gradually grew as mom's blood sugar rose above normal levels, even if she wasn't officially diabetic.
Some doctors already are trying the simpler approach. The Oregon Health & Science University began using it last summer, and gestational diabetes cases doubled, obstetrics chairman Dr. Aaron Caughey told the NIH meeting. But his medical center decided it's worth trying because even women with mild diabetes could benefit from nutritional counseling that insurance doesn't always cover unless they're diagnosed, Caughey said.
Wednesday's report urged doctors also to consider the anxiety that a diagnosis of even mild gestational diabetes can bring.
In Birmingham, Ala., attorney Kira Fonteneau was diagnosed with gestational diabetes after traditional two-step testing. She cried at the news even though doctors made clear she had a very mild case. She wasn't overweight, but diabetes runs in the family.
Armed with a nutritionist's advice and regular blood-sugar checks, Fonteneau quickly changed how she ate, cutting back on carbohydates. She got better.
"Knowledge is power," she said. "You want to have a healthy baby."
Her daughter Sydney, now 2, was born a healthy 5 pounds, 11 ounces. Fonteneau said she bounced back faster, gaining far less during her pregnancy than is typical for her family. She said she will pay more attention to her own health knowing she's at increased risk for Type 2 diabetes later on.
___
Online:
NIH site on gestational diabetes: http://diabetes.niddk.nih.gov/dm/pubs/gestational/
Source: http://news.yahoo.com/more-women-diabetes-care-pregnant-213608694.html
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Tuesday, May 22, 2012
Why Airplanes Still Have Ashtrays in the Bathrooms [Airplanes]
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Ann Arbor Firm Helps Analyze Lethal, Castration-Resistant Prostate ...
ANN ARBOR ? A new study by researchers from the University of Michigan, Yale School of Public Health, Brown University and Ann Arbor-based Compendia Bioscience provided a comprehensive genomic profiling of patients with pre-treated lethal metastatic prostate cancer, providing insights into mechanisms of resistance.
The study, published in the scientific journal Nature, identified a diverse series of likely driving mutations and copy number alterations in both known and novel genes. Oncomine streamlined analysis of genome alterations and provided a platform for rapid validation across previously published studies.
?The Oncomine?tool set was developed to mine the global collection of cancer genomic data ? our most recent advances focusing on mutation and copy number analysis. It is always rewarding to see our platform contributing to scientific discovery,? said Dr. Daniel Rhodes, CEO of Compendia Bioscience.
Integrated analysis of copy number and mutation data identified loss of CHD1, a chromatin-modifying enzyme, as a key genetic event in ETS-negative prostate cancer. With Oncomine, the team was able to rapidly validate this observation across 13 independent, previously published patient cohorts.
?Oncomine?continues to be my go-to reference database to analyze and validate cancer genomic findings,? said Dr. Scott Tomlins, senior author of the study. ?The latest advances in mutation and copy number analysis are quite powerful and the ability to quickly and easily compare multiple data sets is unmatched.?
Compendia Bioscience is dedicated to curing cancers through the application of genomic data by providing researchers with the data and analysis tools necessary to validate biomarker and gene target discoveries, better understand mechanisms of disease, and optimize clinical outcomes. Visit www.compendiabio.com for more information.
Oncomine?combines a rapidly growing compendium of more than 62,000 expertly curated cancer genomic profiles with a sophisticated analysis engine and a powerful web application for data mining and visualization. Oncomine facilitates target discovery and validation and supports the prioritization of tumor populations for drug development. Visit www.oncomine.com for more information.
More at www.compendiabio.com.
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Minecraft mod adds programmable 8-bit computer, lacks cassette deck (video)
Never one to focus exclusively on the very latest hardware, a new mod has brought an 6502 microprocessor to a Minecraft world near you. The system is made from three separate cubes, representing the CPU, monitor and disk drive, respectively, all connected by ribbon cables. Part of pre-release 5 of the RedPower 2 mod, programmer Eloraam has also thrown in pumps and solar panels to keep crafters busy -- you're no longer limited to light switches. The emulated 8-bit processor can interact with other Minecraft blocks and while the computer can be programmed alone, its creator has been kind enough to include a Forth interpreter alongside the hardware, for those looking to get a little more involved. Such types can also skip over the break for an intense 23-minute tutorial on the mod.
Continue reading Minecraft mod adds programmable 8-bit computer, lacks cassette deck (video)
Minecraft mod adds programmable 8-bit computer, lacks cassette deck (video) originally appeared on Engadget on Mon, 21 May 2012 17:16:00 EDT. Please see our terms for use of feeds.
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Sunday, May 20, 2012
news: Conservative politics in the current united states of america ...
The basic tenets of conservative politics were first writ by the philosopher John Locke, an english philosopher and physician who's considered by many to be one of the founding fathers of modern thought. Locke was an atheist who believed in the supremacy of secular humanism - in other words, he believed that if humans were allowed to proceed unencumbered through life by either theocratic superstition or governmental interference, that we could achieve our greatest potential as citizens of the world. His theories were influential from Russia to the Americas, and had a profound impact upon the founding fathers of the united states, with special notation for his contributions to liberal theory.
And that's the funny part: Conservative politics have their roots in liberal theory. Conservatism as it is now, of course, is not Locke's conservatism at all, but that kind of irony tends to be lost on people who consider themselves conservatives.
Conservative politics these days are vastly different from Locke's liberal theory, though of course most conservatives still pay lip service to the notion of non-interference from government interest. Of course, they do so for a different reason. Locke's motivation was to produce a free and unencumbered people able to proceed through life on and by their own means, repressed by none and free to communicate with all.
Conservative politics today, on the other hand, focus on a lack of governmental interference in order to maintain the stratification of the classes. Government policies as a whole tend to be aimed toward things that will help the working and middle classes - stuff like jobs programs, health care, welfare, unemployment benefits and the like. These programs are pricy, but on balance they more than pay for themselves by providing jobs and training and helping the underclass gain some sort of enfranchisement.
Conservative politics tend to say they oppose that - and all government spending - in principle. However, you'll find very few conservatives who oppose military spending, the bank bailout, or other governmental programs that favor big business. So they're clearly not in tune with the principles that Locke put forth. They merely pick and choose the talking points that most favor themselves for their upcoming campaigns.
And that's without even touching Locke's other premise - that religion is superstition and god is a crutch used to oppress the working class. If you can find a single conservative in modern America who held those views, you'd have found literally one-in-a-million.
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